A tendency towards significance was also found for some of the doses used in H358 (Ctrl vs. 2·IC 50 ; p = 0.1) and H23 (Ctrl vs.
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G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1.
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Using patient’s TCGA data we found a highly significant positive correlation between G9a and DNMT1 for both LUAD and LUSC (Fig. 1C ).