Non-tuberculous <i>mycobacteria</i> enhance the tryptophan-kynurenine pathway to induce immunosuppression and facilitate pulmonary colonization.

In the NTM cohort, we observed a significant elevation in biotin metabolism and tryptophan metabolism, while enrichments in pathways such as D-arginine and D-ornithine metabolism, carbon fixation pathways in prokaryotes, sphingolipid metabolism, and N-glycan biosynthesis were noted but did not reach statistical significance.

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