Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation - Relevance to psychiatric and neurodevelopmental illness, and implications for treatment.

6 D), while the effects on Klf2 and Nr4a3 both approached significance (P = 0.0571 and 0.0637 respectively). 4 Discussion RNA-Seq has been used to profile transcriptome-wide changes in gene expression in numerous pathologies (from cancers and cardiovascular diseases to neuropsychiatric illnesses) to elucidate underlying mechanisms and identify new targets for therapeutic intervention (e.g.

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Six of these nine targets (67%) were confirmed by qRT-PCR; Hrh3 , Sod1 , Chrm4 , Lrrk2 , Nr4a1 and Prkca , while a further two (22%) were close to significance; Klf2 and Nr4a3 .

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Isolation-induced down-regulation of Klf2 just failed to reach statistical significance during our qRT-PCR validation of RNA-Seq data, but Krüppel-like factor 2 (KLF2) activators have anti-inflammatory effects in vascular cells ( Xu et al., 2017 ; Lei et al., 2022 ) and any demonstration of similar properties in brain tissue would still be of potential interest.

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