Enhancement of a one-step membrane technique for the treatment of large bone defects by pre-seeding the membrane with CD8 lymphocyte depleted bone marrow mononuclear cells in a rat femoral defect model.

Front Immunol · 2024 · PMC11537973 · PMID 39507531

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did not reach statistical significanceno p-value reported

CD8 cell depletion has no effect on vascularization in the bone defect The fraction of α-SMA positive area decreased in samples transplanted with hADM+BMC-CD8 (median: 0.047%; IQR 0.035 - 0.116) compared to hADM+BMC (0.101%, IQR 0.054 - 0.196) and hADM (0.077%, IQR 0.068 - 0.169), but this comparison did not reach statistical significance, p global = 0.26.

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