Hyperthyroidism, hypothyroidism, thyroid stimulating hormone, and dementia risk: results from the NHANES 2011-2012 and Mendelian randomization analysis.

Front Aging Neurosci · 2024 · PMC11538144 · PMID 39507203

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borderline significanceno p-value reported

A global test with a p -value of 0.05 for the causal relationship between hyperthyroidism and dementia suggested borderline significance, indicating a potential slight pleiotropy; however, no significant aberrant SNPs were identified ( Supplementary Table 7 ).

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weakly significantno p-value reported

In contrast, the nonlinear relationship between serum FT4 concentration and CERAD2 was only weakly significant.

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