High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

A second, highly significant set of associated variants in 1q32.2 was defined by the lead SNP rs570516915 ( P = 5.25 × 10 –34 , OR = 8.65, Fig. 2b ).

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The risk allele A of rs642961, which has a frequency of 22% in the Finnish population, did not reach statistical significance in the Finnish cohort of CL/P cases evaluated here ( P = 0.4), possibly because of the small sample size, and showed nonsignificant negative association with CP (OR = 0.71, 95% CI 0.57–0.89, P = 0.003).

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