The clinical anti-inflammatory effects and underlying mechanisms of silymarin.

79 In the context of NASH, silymarin intake ranging from 140 to 700 mg demonstrated safety and tolerability, with an improvement in hepatic steatosis and lobular inflammation observed in some subjects, although these changes did not reach statistical significance in histological improvement. 80 For patients with cirrhosis, a 12-month regimen of Realsil 100D, comprising silymarin, vitamin D, and vitamin E, significantly improved liver stiffness, suggesting an amelioration of liver fibrosis.

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