Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma.

For HPV + patients, the association of TTK expression was borderline significant ( P = 0.058) with a HR = 0.24, suggesting higher TTK expression is associated with decreased risk of death.

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Depletion of TPR, NUF2, or NDC80 significantly enhanced TNFα-induced apoptosis, whereas PLK1 or AURKA knockdown alone potently induced significant apoptosis, and the increase in apoptotic cells with addition of TNFα approached but did not reach statistical significance ( Fig. 3E ; representative images in Supplementary Fig.

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The inverse relationship between TTK expression and survival in HPV + HNSCCs approached but did not quite reach significance, possibly due to smaller sample size.

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