The novel ROCK2 selective inhibitor NRL-1049 preserves the blood-brain barrier after acute injury.

J Cereb Blood Flow Metab · 2024 · PMC11542141 · PMID 38833563

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hedged sentence

0.0800

closest p · 1.6× alpha

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boldest claim

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a strong trendp = 0.08so close (0.05 < p ≤ 0.1)

NRL-1049 arm showed significantly lower brain water content compared with vehicle controls at 24 hours (p = 0.003) and a strong trend as early as 1 hour (p = 0.08) after cryoinjury (two-way ANOVA followed by Šídák’s multiple comparisons).

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