ECRG4 mediates host response to cutaneous infection by regulating neutrophil recruitment and adhesion receptor expression.

Compared to the controls, however, the T2DM leukocytes demonstrated 31% increased expression of L-selectin (P = 0.015) and 61% increased CD44 (P = 0.032), with an increasing trend in both L-selectin and CD44 in the IFG patients ( Fig 6B–6D ).

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There was a trend towards increased CXCR4 in the ECRG4 KO mouse, which could promote retention of neutrophils in the BM, however this did not reach statistical significance.

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