Effect of concomitant use of yokukansan on steady-state blood concentrations of donepezil and risperidone in real-world clinical practice.

Although the differences in the plasma concentrations at week 0 and week 8 did not reach statistical significance, the 90% CIs of the geometric mean ratio (week 8 to week 0) were outside the bioequivalence range of 0.80–1.25. 13 If we simply estimated based on the results, such as means and standard deviations, observed in this study, 10 and 41 patients were supposed to be sufficient to detect a 50% difference in the steady‐state blood levels of donepezil and risperidone, respectively, between week 0 and week 8, with a power of 0.80 (α‐level of 0.05).

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