Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter?

In a subgroup analysis of patients treated in the standard of care group (i.e., Capecitabine-based CRT) of the RAPIDO trial, which was not stratified by pathologic outcomes, adjuvant CT appeared to improve long-term oncologic outcomes as a function of treatment adherence, but this did not reach statistical significance [ 22 ].

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Without prospective evidence of benefit from additional adjuvant chemotherapy in these patients, we would suggest that surveillance protocols should be more individualized based on the highly significant association between pathological outcome and the incidence of TF.

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