Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle.

Honokiol and NAD treatment significantly decreased the expression of Murf1 , Foxo3a , Cathespin-l , and Atrogin-1 and showed a decreasing trend for Foxo1 in the gastrocnemius ( Figure 6 B). 2.6.

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While Atrogin-1 and Foxo1 expression showed an increasing trend in the gastrocnemius, they did not reach statistical significance ( Figure 6 B).

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