Barely Significant
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Association of Genetic Variants at the <i>CDKN1B</i> and <i>CCND2</i> Loci Encoding p27<i><sup>Kip1</sup></i> and Cyclin D2 Cell Cycle Regulators with Susceptibility and Clinical Course of Chronic Lymphocytic Leukemia.

Int J Mol Sci · 2024 · PMC11546115 · PMID 39519258

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borderline significanceno p-value reported
However, the CDKN1B rs2066827G allele and the CCND2 rs3217901AA genotype were associated with CLL susceptibility with borderline significance.

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of marginal significanceno p-value reported
For the rs36228499 polymorphic site, A+ carriers expressed significantly higher levels of cyclin D2 in CD3+ cells than A− carriers (homozygous CC) ( Table 6 , Figure 2 ); although we observed a similar association in a subset of leukemic CD19+CD5+ cells, it was only of marginal significance.

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