Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT.

Lower baseline uEGF had a borderline significant association with a higher risk of ≥30% eGFR decline in multivariable models adjusting for urine albumin and eGFR ( Table 2 and Figure 2 ).

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Lower uEGF concentrations were found to be associated with increased risks of ESKD, AKI, CVD, and all-cause mortality; however, these associations did not reach statistical significance when the models were controlled for baseline urine albumin and eGFR.

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