Therapeutic targets for lung cancer: genome-wide Mendelian randomization and colocalization analyses.

Furthermore, analyzing the survival curves by Log-rank test, we found that in the TCGA_LUAD dataset, there was a significant difference in survival time between patients with high and low PSMA4 expression (Log-rank test, p = 0.0029), whereas in the GSE19188 dataset, although the correlation between the PSMA4 expression level and survival did not reach statistical significance (Log-rank test, p = 0.55), but the overall trend was consistent with the TCGA_LUAD dataset.

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This finding was highly significant, with a p -value less than 0.001, even after Bonferroni and false discovery rate (FDR) adjustments, underscoring its potential as a therapeutic target ( Yuan et al., 2021 ).

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