High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis.

Upon sgRNA-mediated knockout of RNF31 , MAP3K7 , and IKBKG , there was an increase in the percentage of apoptotic cells in ORL-215 and ORL-174 (except for IKBKG , which did not reach statistical significance), whereas the AZD5582-resistant lines did not show dependency on these genes for survival ( Fig. 3D and E ).

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