Furthermore, thiazide-like diuretics did not show an increase in the risk of cancer occurrence in the intention-to-treat analysis based on first-step drug assumption, which was associated with a small and barely significant increase in cancer risk by loop diuretics.
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Long-term exposure to antihypertensive drugs and the risk of cancer occurrence: evidence from a large population-based study.
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The sentences
Thiazide-like and loop diuretics showed a trend toward an increased risk of cancer as exposure increased, in the context of a relatively small number of patients and events and wide confidence intervals with longer exposures.