Robotic Ultrasound and Novel Collagen Analyses for Polycystic Kidney Disease Research Using Mice.

15 However, the previous study using more advanced disease showed a trend toward a lower cardiac output in Pkd1 RC/RC mice, and another study of these mice with advanced disease showed increased heart weight and thickening of the left ventricular myocardium. 17 In addition to TKV, histological analysis is another standard indicator of PKD severity. 2 , 18 PSR and Masson's trichrome stains for collagen are evaluated using brightfield imaging.

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