Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice.

The IFN-γ inducible protein CXCL10 (IP-10) followed a similar pattern, showing significant up-regulation in EcoHIV-infected mice relative to mock-infected controls, although the difference between EcoHIV-infected and EcoHIVΔNef did not reach statistical significance ( Fig 2F ).

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