The results showed no significant between-group differences (RR, 1.61; 95% CI: 0.78–3.34) and the heterogeneity was not statistically significant, although with a trend toward significance (I 2 =42%; P=0.13).
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Risk of new vertebral compression fractures and serious adverse effects after vertebroplasty: a systematic, critical review and meta-analysis of randomized controlled trials.
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( 15 ) found a lower number of serious adverse effects in patients treated with vertebroplasty compared to placebo/CT, but these differences did not reach statistical significance.