A randomized control trial evaluating the advice of a physiological-model/digital twin-based decision support system on mechanical ventilation in patients with acute respiratory distress syndrome.

For the subsequent post-hoc sub-group analysis of non-ECMO patients ( Table 3 ), the oxygenation index was improved in the intervention arm for patients in support mode (−2.60, 95% CI:-4.13, −1.08; p = 0.0010), with controlled mandatory ventilation showing a numerical improvement although this did not reach statistical significance (−2.66, 95% CI -5.38, 0.06; p = 0.06).

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