Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1).

Nevertheless, when we considered the standard deviations from the means by initial snapshot, we observed a clear trend in the final TM3-TM7 distance which increased from 16.8 ± 0.7 Å, in POPC bilayer without surface tension, to 19.8 ± 0.2 Å, in DOPG bilayer under surface tension ( Fig 3A , right panel).

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