The efficacy and safety of addition of pegylated interferon to long-term nucleos(t)ide analogue therapy on functional cure of chronic hepatitis B patient: a systematic review and meta-analysis.

Compared to NAs monotherapy, sequential combination therapy showed a significant increase in HBeAg seroclearance rate (RR 2.04; 95%CI: 0.47–8.82; I 2 = 73%) and HBeAg seroconversion rate (RR 2.10; 95%CI: 0.41–10.71; I 2 = 67%), but did not reach statistical significance.

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