Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.

Nat Commun · 2024 · PMC11560923 · PMID 39537604

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

nominally significantP = 5.662e −6actually significant

After conditioning on the top variant rs4143332 (LD- r 2 of 0.988 to HLA-B*08:01 ), or complement component 4 ( C4 ) expression levels HLA-C*05:01 remained nominally significant (rs4143332: OR = 0.6869, P = 5.662e −6 , SE = 0.0828; C4 expression: OR = 0.68991SE = 0.0865, P = 1.774e −5 ), indicating partial independence from HLA-B*08:01 and C4 .

also in 7,732 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.