DNA fork remodeling proteins, Zranb3 and Smarcal1, are uniquely essential for aging hematopoiesis.

Bone marrow showed aging Zranb3 ‐deficient mice accumulated neutrophils at the expense of B‐cells, resulting in a strong trend of reduced splenic B‐cells (Figure 5c, d ; Figure S5A–D ).

also in 5,725 other papers

However, there were decreased DNA fiber track lengths in Smarcal1 Δ/Δ MPPs, indicating DNA fork stalling, but this did not lead to more DNA breaks (Figure 2h ), and there was only a slight trend toward reduced MPPs in mice lacking Smarcal1 (Figure 2i ; Figure S2C ; summarized in Table S1 ).

also in 4,078 other papers