Conversely, and consistent with its in vitro effect on maturation, R848 induced the inflammatory cytokines IFN-α, IL-1β, IL-18, IL-6, IL-8, and TNF, as well as antiinflammatory IL-10, and showed a trend for the induction of IFN-γ in LN cells from 5 of 8 donors.
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Innate immune cell activation by adjuvant AS01 in human lymph node explants is age independent.
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