Proton pump inhibitors are detrimental to overall survival of patients with glioblastoma: Results from a nationwide real-world evidence database.

Corticosteroid dependence was of borderline significance in this model, with an increased risk (HR 1.31, p = 0.085).

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Subgroup analysis, stratified on PPI use within the 150-day observation window, suggested that PPI use was associated with reduced mOS and 2-year OS particularly in the population with MGMT- methylated status and in the one with age < 60 years old, but these findings did not reach statistical significance ( Figure 3 ).

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