In this overlapping composite region, the effect of 11 C‐PiB uptake on the MoCA was partially mediated by 11 C‐PK11195 signal (28% and 29% of total effect in left and right hemisphere, respectively); however, the mediation effect of 11 C‐PK11195 binding did not reach statistical significance.
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Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease.
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