An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns.

In the correlation analyses, we found that the SAT bulk expression of the lncRNA, AC002066.1 , was significantly positively correlated with the adipocyte diameter in a BMI-dependent way as a significant correlation was observed in the lower BMI twin siblings from each BMI-discordant MZ pair (adipocyte diameter: Spearman’s rho = 0.55, p adj = 0.0023) ( Figure 5 E; Table S13 ), while the higher BMI twin siblings from each BMI-discordant MZ pair showed only nominally significant p values ( Figure 5 D; Table S13 ).

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We found the difference in module scores between the individuals with and without the rs10494217 T risk allele to be highly significant ( p KOBS = 1.46 × 10 −40 , p RYSA = 3.53 × 10 −22 ), consistently in both cohorts ( Figures 4 B and 4C).

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