Aged mice presented slightly increased anxiety-like behavior; however, the difference between the groups did not reach statistical significance (Fig. 1 ).
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A comparison of cognitive decline in aged mice and mice treated with aftin-4.
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On average, aged mice spent 8.5% more time in the closed arms than did the control ( p = 0.071) and aftin-4 ( p = 0.086) mice, although the effects were only borderline significant according to Tukey’s post hoc test (data not shown).