An AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma.

Interestingly, in this experiment PGC‐1α‐levels were only elevated in LNT‐229 cells incubated with galactose, in G55T2 cells there was only a marginal trend, indicating a temporal delay between AMPK activation and increase in PGC‐1α protein expression that is better detectable after a longer incubation period (Figure S4B ). 3.5.

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p Values < 0.01 and < 0.05 were considered highly significant (**) and significant (*).

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After 7 days of incubation, the mixed cell population showed a trend towards the most prominent tumour growth, followed by the PGC‐1α overexpressing cells and the control cells, however, without achieving statistical significance (Figure S2A–D ). 3.3.

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