Importantly, a high MF signature also revealed a strong trend toward worsened metastasis survival and lung metastasis‐free survival in breast cancer patients with lung metastases (Supplementary Figure S7E ).
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Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.
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