Imetelstat, a novel, first-in-class telomerase inhibitor: Mechanism of action, clinical, and translational science.

E‐R for safety revealed no significant relationship for grade 3/4 neutropenia; however, a positive E‐R relationship was observed for grade 3/4 thrombocytopenia and imetelstat cycle 1 exposure (statistically significant for C max and approaching significance for AUC; Figure 3 ). 20 Importantly, no significant E‐R was seen for safety events considered clinical consequences of these cytopenias, in terms of any grade or grade 3/4 infections or bleeding events (Figure 3 ).

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