Pericyte response to ischemic stroke precedes endothelial cell death and blood-brain barrier breakdown.

There was a clear trend suggesting Occludin decreases at 6 and 24 hours, however, it did not reach significance (p = 0.87 and p = 0.92), whereas reduction in the Occludin levels at 12 hours was statistically significant (ZO-1 ipsilateral hemispheres: Ctrl: 146.11 ± 39.8%, 1 h: 106.1 ± 47.2%, 3 h: 115.3 ± 34.6%; 6 h: 51.2 ± 22.4%, 12 h: 37.2 ± 15.3%, 24 h: 44.3 ± 19.6%; Occludin ipsilateral hemispheres: Ctrl: 130.8 ± 32.5%, 1 h: 99.9 ± 61.3%, 3 h: 109.4 ± 53.1%; 6 h: 46.8 ± 40.0%, 12 h: 28.8 ± 12.7%, 24 h: 47.3 ± 32.4%) ( Figure 4(a) to (c) ).

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