Even though the three studies with low and moderate risks of bias were not suitable for meta-analysis, the very large sample size in the HALT-IT study (12,009 patients), which has a low risk of bias, alone makes the results of this study highly significant [ Supplementary File 4 ] ( https://turkjemergmed.com/pages/2024-4-issue-supplementary-files ).
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The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024.
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When the analysis excluded patients with a GCS of 3 and no pupillary response, the difference between the groups increased slightly but did not reach statistical significance (TXA 12.5% vs. placebo 14%, RR: 0.89, 95% CI: 0.80–1.00).