Chronic low-grade inflammation in patients with systemic sclerosis is associated with increased risk for arteriosclerotic cardiovascular disease.

In addition, we noted in the overall SSc cohort a weak positive correlation between CRP levels and the right carotid intima–media thickness (CIMT right) ( ρ = 0.283, p = 0.041) and an almost significant correlation between CRP levels and the mean CIMT left and right (ρ = 0.227, p = 0.071).

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25.8 kg/m 2 , p = 0.037), used significantly more often glucocorticoids ( p = 0.023), significantly less often hydroxychloroquine ( p = 0.012) and showed a statistical trend toward having on average an almost 2-year shorter SSc disease duration.

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The individual Framingham risk scores for hard coronary heart disease were numerically higher in the CRP+ SSc group but did not reach statistical significance.

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