Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes.

Although the immunohistochemical staining signal was not able to reach the levels of the CTR in any of the study groups ( p < 0.001 for all comparisons with CTR), we found that CLDN expression significantly increased from day 2 to day 14 of follow-up, although correlation with time did not reach statistical significance (Fig. 3 B and Additional File 2: Table S2).

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