Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.

A clear trend for faster tracer displacement was therefore observed for compounds with high k inact / K i (>20 × 10 −5 nM −1 s −1 , 1, 2, 9), as compared to compounds with low k inact / K i (<10 × 10 −5 nM −1 s −1 , 6, 7 and CNX1351).

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