Central venous catheter-related infections: a systematic review, meta-analysis, trial sequential analysis and meta-regression comparing ultrasound guidance and landmark technique for insertion.

While individual analyses of studies measuring CRBSI or CLABSI alone did not reach statistical significance, the pooled analysis of these outcomes (composite secondary outcome) demonstrated a significant reduction of CLABSI or CRBSI with US-guided CVC (RR = 0.65, 95% CI 0.48–0.87).

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