Kidney Injury Evoked by Fine Particulate Matter: Risk Factor, Causation, Mechanism and Intervention Study.

In response to pre‐incubation with NAC, the levels of pyroptosis markers NLRP3, ASC, Caspase1 and GSDMD in the HK‐2 cells decreased or showed a decreasing trend when compared with the PM 2.5 ‐treated group (Figure 5L,M ).

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Mechanistically, the levels of pyroptosis markers NLRP3, Caspase1 and GSDMD were decreased or showed a trend toward decrease in the kidney of PM 2.5 ‐exposed mice treated with NAC (Figure 7H,I ).

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