Increased potentiation of 5-fluorouracil induced thymidylate synthase inhibition by 5,10-methylenetetrahydrofolate (arfolitixorin) compared to leucovorin in patients with colorectal liver metastases; The Modelle-001 Trial.

The present study, despite including a low number of patients, showed that administration of 120 mg/m 2 Arfo led to higher MeTHF levels compared to 30 mg/m 2 Arfo and 60 mg/m 2 LV, and a higher TS inhibition in the A120 group compared to LV60 although the difference did not reach statistical significance.

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