Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.

The 12 decline-associated variants were enriched for directionally consistent nominally significant association with rapid decline and eGFR-decline in CKD ( P enrich =1.6 × 10 − 8 or 2.2 × 10 −3 , respectively), but the 11 stable-effect variants were not ( P enrich = 1.0 or 0.43, respectively; Fig. 3b and Supplementary Table 6 ).

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