Associations of genetic variation and mRNA expression of PDGF/PDGFRB pathway genes with coronary artery disease in the Chinese population.

It was found that PDGFC mRNA levels significantly differed across the AA, AG and GG genotypes of PDGFC variant rs6845322 in the control group ( p = 0.002), and the expression showed a decreasing trend as the number of the mutant allele increased ( p for trend = 3.4 × 10 −4 ) (Figure 4 ).

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This association did not reach statistical significance after FDR adjustment ( P FDR = 0.063).

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