Our results suggest that within the overweight and obese population, there may be reduced renal secretion and increased risk of nephrotoxicity (impaired efflux from tubular epithelial cells) since ABCC2 (MRP2) correlated significantly with BMI and showed a trend towards down-regulation (by 2.6-fold) in overweight and obese subjects when compared to lean individuals [ 31 ].
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Obesity-related drug transporter expression alterations in human liver and kidneys.
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