Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease.

Dis Model Mech · 2024 · PMC11583919 · PMID 39526491

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did not reach statistical significanceno p-value reported

When mHTT was reduced in astrocytes of BACHD/GFAP-CreER T2 mice, there was significant improvement in brain weight and striatal volume compared to that in BACHD mice, although changes in cortical volume did not reach statistical significance ( Wood et al., 2019 ).

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