Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics.

However, when performing analyses using the IPA variable, no association was found between this variant and on‐ticagrelor IPA regardless of agonist or concentration used, suggesting that nominally significant associations observed in analyses of maximal platelet aggregation data were caused by differences in baseline platelet aggregation and not due to a pharmacogenetic relationship between CES1 and ticagrelor.

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