Spatial distributions of CD8 and Ki67 cells in the tumor microenvironment independently predict breast cancer-specific survival in patients with ER+HER2- and triple-negative breast carcinoma.

Meanwhile, the tumor edge demonstrated lower CD8+ cell densities and less dispersion when compared to the IZ stroma aspect in the ER+HER2– BC subgroup ( p < 0.0001) ( Fig 2A ); however, this difference did not reach statistical significance in TNBC patients ( p = 0.14, Fig 2B ).

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[ 44 ], who observed a positive trend between CD8+ density in tumor region and clinical outcomes in a cohort of 236 patients with ER+ invasive BC using machine learning-based approach.

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