In particular, Gabra1 expression showed contrasting trends depending on the sex of the animal, being significantly increased in male HEM (+/Y) compared to WT (X/Y) (Student's t-test, p = 0.0429) and showing a trend towards reduced in female HOM (+/+) compared to WT animals (X/X), that did not reach statistical significance ( Fig. 6 J).
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A new knockin mouse carrying the E364X patient mutation for CDKL5 deficiency disorder: neurological, behavioral and molecular profiling.
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