Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure.

23 Although it did not reach statistical significance in this small sampling, the relationship of ACE‐S to [Cl − ] appeared to be direct, supporting chloride's role in enzyme activation. 21 , 24 This dog did not receive ACE inhibitor medication, making the interpretation of the results surrounding the RAAS cascade clearer than if medical inhibition was provided.

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